Figure 5
From: microRNA blood signature for localized radiation injury
Validation analysis. (A) sPLS-DA using 8 validated miRNA is able to distinguish controls, 20 Gy and 80 Gy groups from each other, while the 40 Gy group appears to be intermediate. (B) Features included in sPLS analysis are plotted with their loading values. The loadings represent the contribution (coefficients in a linear combination) of the selected original miRNAs in the component. Colours indicate the dose group in which the median is maximum for each miRNA. (C) ROC curves representative of the 8-miRNA signature ability to distinguish each group of doses from the others, with the corresponding AUCs and p-values (outcome). (D) Heat map depicting correlations between miRNA plasma expression levels and the injury score (day 7, 10 and 14) and plasmatic CRP concentration (positive correlations in red and negatives in blue). Control group N = 8; 20 Gy N = 10; 40 Gy N = 13; 80 Gy N = 5.
