Table 3 Crude Odds ratio (OR) between independent variables and breast cancer stages.
From: Ambient air pollutants and breast cancer stage in Tehran, Iran
Variables |  < 50 year (n = 633) |  ≥ 50 year (n = 515) | ||||
---|---|---|---|---|---|---|
 | Stage I (n = 115) | Stage II (n = 206) | Stages III & IV (n = 212) | Stage I (n = 109) | Stage II (n = 203) | Stages III & IV (n = 149) |
Education level (Ref: Academic) | ||||||
 Diploma | 1.28 (0.64–2.56) | 1.37 (0.72–2.62) | 1.35 (0.71–2.58) | 0.67 (0.27–1.68) | 0.80 (0.34–1.89) | 0.62 (0.24–1.57) |
 Under diploma | 0.26 (0.10–0.63)* | 0.66 (0.34–1.31) | 0.58 (0.29–1.16) | 0.61 (0.24–1.54) | 0.94 (0.39–2.21) | 1.50 (0.62–3.66) |
Marital status (Ref = single) |  |  |  |  | ||
 Married | 1.21 (0.49–2.93) | 1.74 (0.75–4.06) | 1.57 (0.69–3.59) | †| †| †|
 Divorced/ Widowed | 1.15 (0.16–8.27) | 2.81 (0.50–15.77) | 1.39 (0.23–8.51) | †| †| †|
Smoking status (Ref = No) | ||||||
 Yes | 0.25 (0.04–1.42) | 0.69 (0.20–2.36) | 0.64 (0.18–2.35) | 0.70 (0.16–3.01) | 0.81 (0.22–3.01) | 1.10 (0.29–4.21) |
 Secondhand smoke | 1.00 (0.32–3.10) | 0.68 (0.22–2.06) | 1.29 (0.46–3.62) | 2.46 (0.29–20.95) | 2.25 (0.28–17.96) | 4.98 (0.63–39.06) |
Diabetes (Ref = No) | ||||||
 Yes | 1.34 (0.14–14.04) | 2.45 (0.30–20.03) | 1.01 (0.11–9.42) | 1.67 (0.18–15.42) | 4.13 (0.52–32.93) | 7.21 (0.90–57.71) |
Family history of BC(Ref = No) | ||||||
 Yes | 1.76 (0.85–3.65)* | 1.09 (0.55–2.17) | 1.02 (0.51–2.05) | 0.69 (0.30–1.56) | 0.59 (0.28–1.28) | 0.85 (0.39–1.85) |
Age at first menstruation, year (Ref =  ≤ 12) | ||||||
 > 12 | 1.13 (0.62–2.06) | 1.52 (0.89–2.56) | 1.36 (0.81–2.30) | 1.16 (0.58–2.34) | 1.19 (0.63–2.27) | 1.03 (0.53–2.02) |
Age at first pregnancy, year (Ref: < 30) | ||||||
 ≥ 30 | 1 (0.27–3.71) | 0.62 (0.17–2.19) | 0.78 (0.22–2.69) | 0.76 (0.18–3.21) | 1.70 (0.48–5.99) | 1.79 (0.49–6.52) |
Number of pregnancies (Ref: No) | ||||||
 1 and 2 | 2.58 (1.29–5.13)* | 2.92 (1.58–5.39)* | 2.12 (1.17–3.83)* | 5.46 (1.90–15.71)* | 4.07 (1.48–11.19)* | 1.10 (0.36–3.32) |
 ≥ 3 | 2 (1.04–3.86)* | 2.21 (1.24–3.96)* | 1.27 (0.72–2.25) | 2.29 (1.02–5.13)* | 3.65 (1.76–7.56)* | 2.42 (1.18–4.96)* |
Number of deliveries (Ref: No) | ||||||
 1 and 2 | 2.59 (1.37–4.87)* | 2.58 (1.47–4.51)* | 1.89 (1.10–3.26)* | 4.13 (1.68–10.11)* | 3.77 (1.63–8.71)* | 1.31 (0.54–3.16) |
 ≥ 3 | 1.96 (0.94–4.07) | 1.99 (1.05–3.80)* | 1.12 (0.58–2.14) | 2.23 (0.97–5.13) | 3.65 (1.73–7.72)* | 2.79 (1.33–5.88)* |
Estrogen/Progesterone receptor status (ERPR status) (Ref: ER−PR-) | ||||||
 ER + PR +  | 1.02 (0.34–3.02) | 0.78 (0.27–2.25) | 0.73 (0.25–2.09) | †| †| †|
 ER + PR- | 0.56 (0.08–3.82) | 0.68 (0.12–3.89) | 1.06 (0.19–5.95) | †| †| †|
 ER−PR +  | 0.91 (0.08–9.98) | 0.31 (0.03–3.59) | 0.64 (0.06–6.42) | †| †| †|
Number of metastatic lymph nodes (Ref: No) | ||||||
 < 5 | 2 (0.11–35.81) | 19.33 (2.30–160.2)* | 0.68 (0.11–4.19) | 0.49 (0.03–8.07) | †| †|
 ≥ 5 | 2.34 (0.21–26.17) | 0.81 (0.13–4.97) | 0.01 (0.00–0.05)* | †| †| †|
Air pollution | ||||||
 PM10 (μg/m3)** | 1.04 (0.97–1.12) | 1.01 (0.94–1.07) | 1.03 (0.96–1.09) | .98 (0.89–1.07) | 1.00 (0.92–1.08) | 1.01 (0.93–1.10) |
 SO2 (ppb) | 0.99 (0.92–1.06) | 1.00 (0.94–1.07) | 0.98 (0.93–1.05) | 0.93 (0.86–1.02) | 0.97 (0.90–1.05) | 0.91 (0.84–0.99)* |
 NO2 (ppb) | 1.08 (0.97–1.21) | 1.03 (0.93–1.14) | 1.02 (0.93–1.14) | 0.98 (0.85–1.13) | 0.97 (0.85–1.11) | 0.95 (0.83–1.09) |
 NO (ppb) | 1.06 (1.01–1.12)* | 1.04 (0.99–1.09) | 1.03 (0.98–1.08) | 0.96 (0.89–1.08) | 1.00 (0.94–1.07) | 1.01 (0.94–1.07) |
 NOX (ppb) | 1.02 (0.99–1.05) | 1.00 (0.98–1.03) | 0.99 (0.97–1.02) | 0.98 (0.95–1.02) | 0.99 (0.97–1.02) | 0.98 (0.96–1.02) |
 Benzene (μg/m3) | 3.78 (1.22–11.78)* | 2.04 (0.72–5.80) | 0.97 (0.33–2.82) | 0.69 (0.19–2.52) | 1.27 (0.40–4.05) | 1.43 (0.44–4.71) |
 Toluene (μg/m3) | 1.54 (1.05–2.24)* | 1.25 (0.88–1.76) | 1.13 (0.80–1.59) | 0.88 (0.56–1.39) | 1.16 (0.77–1.74) | 1.22 (0.81–1.58) |
 Ethylbenzene (μg/m3) | 9.98 (1.85–58.82)* | 3.18 (0.67–15.03) | 1.57 (0.33–7.51) | 0.48 (0.07–3.21) | 1.41 (0.26–7.62) | 2.08 (0.36–11.75) |
 P-xylene(μg/m3) | 6.61 (0.89–48.55) | 2.14 (0.34–13.44) | 1.36 (0.22–8.63) | 0.44 (0.05–3.53) | 1.93 (0.35–10.75) | 1.79 (0.31–10.49) |
 O-xylene(μg/m3) | 4.21 (0.94–18.89) | 1.63 (0.41–6.55) | 1.31 (0.33–5.27) | 0.63 (0.09–4.19) | 1.44 (0.26–7.99) | 2.77 (0.48–16.16) |
 m-xylene(μg/m3) | 2.55 (1.15–5.67)* | 1.52 (0.72–3.19) | 1.09 (0.52–2.31) | 0.83 (0.33–2.04) | 1.28 (0.57–2.90) | 1.29 (0.56–2.99) |
 TBTEX (μg/m3) | 1.24 (1.05–1.46)* | 1.09 (0.94–1.27) | 1.07 (0.92–1.24) | 0.95 (0.79–1.13) | 1.06 (0.92–1.23) | 1.04 (0.89–1.22) |
Multipollutant level (Ref: Quartile 1-low) | ||||||
 Quartile 2 | 0.77 (0.37–1.63) | 0.81 (0.43–1.53) | 1.02 (0.54–1.92) | 1.02 (0.42–2.05) | 0.92 (0.41–2.05) | 0.98 (0.42–2.27) |
 Quartile 3 | 1.03 (0.49–2.15) | 0.78 (0.40–1.48) | 0.95 (0.49–1.81) | 1.48 (0.58–3.78) | 1.51 (0.63–3.57) | 1.82 (0.75–4.44) |
 Quartile 4-high | 2.75 (1.18–6.39)* | 2.29 (1.06–4.95) * | 2.07 (0.95–4.52) | 1.05 (0.43–2.57) | 0.90 (0.39–2.05) | 0.99 (0.42–2.34) |
Highway proximity (Ref: > 800 m) | ||||||
 < 400 m | 1.03 (0.51–2.08) | 1.27 (0.67–2.41) | 0.78 (0.41–1.47) | 0.94 (0.39–2.24) | 1.08 (0.49–2.38) | 1.68 (0.74–3.82) |
 400–800 m | 0.81 (0.41–1.58) | 1.14 (0.62–2.09) | 0.86 (0.47–1.55) | 1.12 (0.51–2.49) | 0.88 (0.42–1.83) | 1.26 (0.52–2.45) |