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Figure 1

From: Vitamin D3 deficiency and osteopenia in spastic paraplegia type 5 indicate impaired bone homeostasis

Figure 1

This figure illustrates the vitamin D3 metabolism and the involved organs (skin, liver, kidney, and bone). Both enzymes (highlighted by red lightening) are affected in the liver. For Hereditary Spastic Paraplegia Type 5 (SPG5) there is a defect in CYP7B1 and in Cerebrotendinous Xanthomatosis (CTX) in CYP27A1. Critical pathways of bone homeostasis are shown on the bottom. OPG osteoprotegerin (a sRANKL antagonist), sRANKL soluble receptor activator of nuclear factor-κB ligand (sRANKL).

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