Figure 1

Neurogenesis-associated genes with coding non-synonymous SNPs in the C58/J strain. In silico analysis of coding non-synonymous (Cn) single-nucleotide polymorphisms (SNPs) in genes relevant to adult neurogenesis in the mouse DG. (A) Among the 397 genes associated with processes (left) and cell stages (right) involved in adult neurogenesis, according to the MANGO database (data inside the large circle), 33 genes carried at least one Cn SNP in C58/J mice (data inside the small circle). (B) Among the genes characterizing the genetic profile of neural stem cells (NSC) (591 genes) and neural progenitors (1065 genes) in the mouse DG, as reported by Artegiani (2017) (data inside the large circle), 142 genes carried at least one Cn SNP in C58/J mice, with 64 genes corresponding to NSC and 78 genes to the neural progenitors (data inside the small circle). (C) The 33 genes reported by the MANGO database display from 1 to 16 Cn SNPs in C58/J mice in comparison with the control C57BL/6 J strain. (D) The genes with Cn SNPs in C58/J mice are expressed during specific neurogenic processes (upper panel: proliferation, differentiation, survival, dendritogenesis, migration, maturation) and throughout different cell stages (inferior panel: stem cells [Type 1], undetermined progenitors [Type 2a], determined progenitors [Type 2b], neuroblast-like cells [Type 3], immature neurons, mature neurons, DCX-positive cells), according to the MANGO database. (E) 64 and 78 genes corresponding to the NSC (upper panel) and neural progenitors’ (inferior panel) datasets, respectively, display from 1 to 23 Cn SNPs in C58/J mice.