Figure 4 | Scientific Reports

Figure 4

From: HIF-2α-dependent TGFBI promotes ovarian cancer chemoresistance by activating PI3K/Akt pathway to inhibit apoptosis and facilitate DNA repair process

Figure 4

The role of TGFBI in ovarian cancer chemoresistance. (a) Evaluation of TGFBI sensitivity to chemotherapy drugs on tumor. (b) Cell survival between A2780 and A2780/CDDP followed by the concentration gradient stimulation of cisplatin. (c) The mRNA and protein expression level of TGFBI in cisplatin-sensitive ovarian cancer cell line-A2780 and cisplatin-resistant ovarian cancer cell line-A2780/CDDP. (d) The protein expression level of TGFBI after time gradient of cisplatin in A2780 (IC50 as 119.2 μM). (e) The protein expression level of TGFBI after time gradient of cisplatin in A2780/CDDP (IC50 as 258.8 μM). (f) The protein expression level of TGFBI after knocking down by siRNA in A2780/CDDP. (g) Cell survival after A2780/CDDP were transfected with siRNA, followed by the concentration gradient stimulation of cisplatin (0, 2.5, 5, 10, 20, 40, 80, 160, 320 and 640 μM).

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