Figure 5 | Scientific Reports

Figure 5

From: HIF-2α-dependent TGFBI promotes ovarian cancer chemoresistance by activating PI3K/Akt pathway to inhibit apoptosis and facilitate DNA repair process

Figure 5

TGFBI promoted chemoresistance through inhibiting apoptosis and facilitating DNA damage repair via activating PI3K/Akt signaling pathway. (a) The protein expression level of MRP1 and MDR1 in A2780/CDDP after TGFBI knockdown. (b) The protein expression level of Homologous Recommendation DNA repair related markers in A2780/CDDP after TGFBI knockdown. (c) The protein expression level of Non-Homologous End Joining (NHEJ) DNA repair related markers in A2780/CDDP after TGFBI knockdown. (d) The KEGG enrichment pathway analysis of TGFBI-related differentially expressed genes in OC. (e) The protein expression level of PTEN, PI3K/p110, PI3K/p85, p-Akt, Akt, BCL2, Bax and Beclin1 in A2780/CDDP after TGFBI knockdown.

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