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Figure 1

From: Genome-wide epistasis analysis reveals gene–gene interaction network on an intermediate endophenotype P-tau/Aβ42 ratio in ADNI cohort

Figure 1

The main effect and interaction effect of 961 SNP-SNP interaction pairs at P-tau/A\(\beta _{42}\) ratio level, and R square of the additive terms and the interaction terms. (a) The waterfall comparison plot of interaction effects and main effects of single SNP with −log10 adjusted p-value. The bule waterfall represents main effects of SNP\(_1\), the green waterfall represents main effects of SNP\(_2\), the orange waterfall represents the interaction effects of SNP\(_1\) \(\times\)SNP\(_2\). (b) The violin distribution of interaction effects (SNP\(_1\) \(\times\)SNP\(_2\)) data and main effects (SNP\(_1\), SNP\(_2\)) data. (c) The waterfall comparison plot of the R square of SNP\(_1\) \(\times\)SNP\(_2\) term (orange waterfall) and the R square of SNP\(_1\) + SNP\(_2\) term (green waterfall). (d) The violin distribution of R square: interaction (SNP\(_1\) \(\times\)SNP\(_2\)) and additive terms (SNP\(_1\) + SNP\(_2\)).

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