Figure 3
From: High-dose exposure to butylparaben impairs thyroid ultrastructure and function in rats
BuP exposure induced ultrastructural changes in thyroid epithelial cells. (A) Ultrastructure of normal thyroid epithelial cells from the control group. The mitochondria, rough endoplasmic reticulum, secretory granules, lysosomes, and microvilli are all clear. (B) Ultrastructure of thyroid epithelial cells from BuP-exposed rats. The cells were edematous and the organelles were swollen. Mitochondria were enlarged and vacuolated. Rough endoplasmic reticulum was enlarged. Secretory granules were reduced. Microvilli were reduced. Some autophagolysosomes were visible. Transmission electron microscopy. scale bar = 5 µm (left images), 2 µm (right images). n = 5. Abbreviations: M, mitochondria; RER, rough endoplasmic reticulum; G, secretory granules; Ly, lysosomes; Mv, microvilli; TPO, thyroid peroxidase; Tg, thyroglobulin; ASS , autophagolysosomes.
