Figure 5 | Scientific Reports

Figure 5

From: Hygrothermal stress increases malignant arrhythmias susceptibility by inhibiting the LKB1-AMPK-Cx43 pathway

Figure 5

Activation of the AMPK by AICAR injection inhibits HHS-induced myocardial injury and fibrosis. (A) Representative HE staining results of rat myocardial tissues in all groups. (a) Normal expression of myocardial structure of NC group; (b) Alterations in Myocardial Structure in the HHS Group; (c) Improvements in myocardial structure in the A + HHS group. (B) Ultrastructural deformation of rat cardiomyocytes in each group was shown by TEM imaging. (a–c) Normal ultrastructure of the NC group; (d–f) Ultrastructural alterations in the HHS group; (g–i) Improvements of ultrastructure of A + HHS group. (C) Typical Masson staining for fibrosis that stained in blue. (a) Normal Masson staining manifestation in NC group; (b) Significant fibrotic changes in HHS group; (c) Improvement of fibrosis in A + HHS group; (d) Quantification of the fibrotic area of the Masson-stained sections (n = 6). (D) Western Blot Analysis of ST2, a Marker of Myocardial Fibrosis. (a) Western Blot demonstration of ST2; (b) Quantification of the ST2 level (n = 4). ****P < 0.0001.

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