Table 3 Univariate mediation analysis revealed the mediating role of anemia biomarkers in the association between the eGFR and all-cause mortality.

From: The estimated mediating roles of anemia-related variables in the association between kidney function and mortality: a National Health and Nutrition Examination Survey (NHANES) study

 

Hb

Hct

RDW

MCHC

Mediation (%)

95% CI

Mediation (%)

95% CI

Mediation (%)

95% CI

Mediation (%)

95% CI

Total

14.84

8.62 to 21.07

15.14

9.22 to 21.07

36.48

29.96 to 43.01

0.21

− 6.12 to 6.53

Age groups (years)

 20–45

152.48

NA*

26.26

NA

88.42

NA

− 56.37

NA

 46–64

8.15

− 1.30 to 17.60

2.62

− 2.01 to 9.21

16.3

4.62 to 36.12

− 1.67

6.55 to 1.34

 65 or older

22.70

18.09 to 27.32

22.71

18.33 to 27.09

25.11

20.56 to 29.66

0.14

− 4.47 to 4.75

eGFR groups

 Early CKD

12.20

10.90 to 13.50

11.88

10.70 to 13.07

− 3.32

− 4.69 to − 1.95

− 0.23

− 1.48 to 1.01

 CKD

17.55

16.52 to 18.58

17.60

16.36 to 18.84

36.19

34.76 to 37.61

0.15

− 1.01 to 1.31

Hb groups

 Anemia

29.30

27.98 to 30.62

28.28

27.19 to 30.62

13.04

12.01 to 14.06

− 1.06

− 1.96 to − 0.16

 No anemia

-0.22

− 0.52 to 0.07

− 0.19

− 0.58 to 0.20

43.11

42.72 to 43.49

− 0.04

− 0.38 to 0.30

  1. The mediation % presents the proportion of all mediating effects attributed to an anemia biomarker, for the association between CKD and all-cause mortality.
  2. The bold text indicates a statistical significance according to the 95% confidence interval.
  3. CKD chronic kidney disease, Hb hemoglobin, Hct hematocrit, RDW red cell distribution width, MCHC mean corpuscular hemoglobin concentration, eGFR estimated glomerular filtration rate.
  4. *NA: not applicable due to the convergence problem (the confidence interval could not be estimated from the resampling method due to the insufficient sample size and the resultant convergence problem in the Cox proportional hazard model).
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