Figure 4

Functional analysis of differentially expressed genes. (A) GO enrichment analysis. The GO enrichment analysis results showed that organic substances, chemical stimuli and chemicals were significantly enriched in RA. (B–D) The top five BP, CC, MF related gene network diagrams,they all involve the gene MMP9. (E) KEGG enrichment analysis. KEGG results showed that IL-17, TNF signaling pathways and HIF-1 signing pathway were significantly enriched in RA.