Table 2 Univariate and multivariate analyses.

From: Establishment and validation of a nomogram model for predicting the specific mortality risk of melanoma in upper limbs based on the SEER database

 

Univariate analysis

Multivariate analysis

HR (95%CI)

Z (P)

HR (95%CI)

Z (P)

Age

1.027 (1.021–1.033)

9.169 (< 0.001)

1.019 (1.012–1.025)

5.753 (< 0.001)

Marriage

 Married

Ref

NA

Ref

NA

 Unmarried

1.571 (1.349–1.828)

5.823 (< 0.001)

1.259 (1.063–1.492)

2.670 (< 0.05)

Sex

 Male

Ref

NA

Ref

NA

 Female

0.484 (0.411–0.571)

− 0.866 (< 0.001)

0.636 (0.532–0.759)

− 4.991 (< 0.001)

Race

 White

Ref

NA

Ref

NA

 Other

2.557 (1.560–4.190)

3.726 (< 0.001)

2.005 (1.153–3.486)

2.465 (< 0.05)

Laterality

 Left

Ref

NA

Ref

NA

 Right

0.995 (0.857–1.157)

− 0.059 (0.95)

1.116 (0.952–1.310)

1.351 (0.18)

Stage

 I

Ref

NA

Ref

NA

 II

6.994 (5.734–8.530)

19.191 (< 0.001)

1.973 (1.382–2.816)

3.743 (< 0.001)

 III/IV

21.749 (17.900–26.427)

30.989 (< 0.001)

3.846 (1.707–8.666)

3.250 (< 0.05)

Tstage

 T1

Ref

NA

Ref

NA

 T2

5.872 (4.789–7.200)

17.016 (< 0.001)

2.013 (1.406–2.881)

3.825 (< 0.001)

 T3/T4

17.415 (13.968–21.710)

25.399 (< 0.001)

2.396 (1.416–4.052)

3.258 (< 0.05)

Nstage

 N0

Ref

NA

Ref

NA

 N1

7.716 (6.379–9.333)

21.143 (< 0.001)

0.862 (0.377–1.969)

− 0.353 (0.72)

 N2/N3

12.219 (9.872–15.126)

22.997 (< 0.001)

1.041 (0.461–2.354)

0.097 (0.92)

Mstage

 M0

Ref

NA

Ref

NA

 M1

26.163 (18.529–36.941)

18.545 (< 0.001)

2.065 (1.011–4.216)

1.991 (< 0.05)

Surgery

 Surgery1

Ref

NA

Ref

NA

 Surgery2

1.709 (1.471–1.986)

7.009 (< 0.001)

1.146 (0.967–1.358)

1.576 (0.11)

Distant LN

 None

Ref

NA

Ref

NA

 1–3

2.563 (1.732–3.794)

4.705 (< 0.001)

1.664 (0.992–2.791)

1.928 (0.054)

 > 4

8.150 (6.397–10.380)

16.989 (< 0.001)

1.936 (1.268–2.954)

3.062 (< 0.05)

 Others

2.508 (2.109–2.983)

10.388 (< 0.001)

1.647 (1.132–2.394)

2.612 (< 0.05)

Surg Oth Reg

 None

Ref

NA

Ref

NA

 Yes

5.349 (3.595–7.963)

8.266 (< 0.001)

0.765 (0.466–1.256)

− 1.059 (0.29)

Radiation

 No

Ref

NA

Ref

NA

 Yes

10.284 (7.514–14.074)

14.557 (< 0.001)

1.337 (0.892–2.006)

1.406 (0.16)

ChemOtherapy

 No

Ref

NA

Ref

NA

 Yes

9.401 (6.756–13.082)

13.294 (< 0.001)

1.332 (0.864–2.054)

1.298 (0.19)

 Breslow

1.388 (1.360–1.416)

31.219 (< 0.001)

0.994 (0.928–1.065)

− 0.159 (0.87)

LDH

 Unhigh

Ref

NA

Ref

NA

 High

2.229 (1.652–3.010)

5.236 (< 0.001)

1.050 (0.722–1.527)

0.257 (0.8)

 Mitotic

1.261 (1.242–1.280)

29.779 (< 0.001)

1.062 (1.035–1.089)

4.590 (< 0.001)

Ulceration

 No

Ref

NA

Ref

NA

 Yes

6.769 (5.827–7.865)

24.995 (< 0.001)

1.524 (1.241–1.871)

4.022 (< 0.001)

Lnpositive

 No

Ref

NA

Ref

NA

 Yes

1.189 (1.018–1.389)

2.188 (< 0.05)

1.834 (1.278–2.632)

3.293 (< 0.001)

DX_bone

 No

Ref

NA

Ref

NA

 Yes

42.715 (19.536–93.393)

9.407 (< 0.001)

3.167 (1.587–6.317)

3.271 (< 0.05)

DX_brain

 No

Ref

NA

Ref

NA

 Yes

59.745 (29.236–122.092)

11.217 (< 0.001)

4.044 (1.887–8.665)

3.593 (< 0.001)

DX_liver

 No

Ref

NA

Ref

NA

 Yes

48.275 (19.546–119.7099)

8.391 (< 0.001)

1.637 (0.602–4.449)

0.966 (0.33)

DX_lung

 No

Ref

NA

Ref

NA

 Yes

29.639 (18.632–47.145)

14.311 (< 0.001)

1.927 (0.897–4.138)

1.682 (0.093)

Tumor size

 < 2

Ref

NA

Ref

NA

 2–10

2.864 (2.279–3.597)

9.042 (< 0.001)

1.261 (0.956–1.662)

1.641 (0.1)

 Other

0.877 (0.745–1.033)

− 1.571 (0.12)

0.935 (0.786–1.111)

− 0.765 (0.44)

Tumor number

 Single

Ref

NA

Ref

NA

 Multiple

1.138 (0.978–1.325)

1.669 (0.095)

0.833 (0.649–1.069)

− 1.435 (0.15)

First malignant primary

 No

Ref

NA

Ref

NA

 Yes

0.719 (0.611–0.848)

− 3.923 (< 0.001)

0.670 (0.513–0.875)

− 2.937 (< 0.05)

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