Table 2 Univariate and multivariate analyses for OS in patients with P-MEC.
Characteristics | Univariable analysis | Multivariable analysis | ||
---|---|---|---|---|
HR (95% CI) | P-value | HR (95% CI) | P-value | |
Age |  |  < 0.001 |  |  |
  < 40 | Reference |  | Reference |  |
 40–50 | 1.453 (0.628–3.363) | 0.383 | 1.305 (0.561–3.036) | 0.536 |
 50–60 | 3.282 (1.656–6.505) |  < 0.001 | 2.594 (1.286–5.234) | 0.008 |
 60–70 | 7.195 (3.766–13.746) |  < 0.001 | 5.936 (3.016—11.681) |  < 0.001 |
  ≥ 70 | 18.925 (10.379—34.508) |  < 0.001 | 11.962 (6.303—22.703) |  < 0.001 |
Gender |  |  < 0.001 |  |  |
 Female | Reference |  | Reference |  |
 Male | 2.112 (1.563–2.855) |  < 0.001 | 1.101 (0.797–1.522) | 0.560 |
Race |  |  < 0.001 |  |  |
 White | Reference |  | Reference |  |
 Black | 0.533 (0.319–0.891) | 0.016 | 1.444 (0.840–2.483) | 0.184 |
 Other | 0.437 (0.237–0.806) | 0.008 | 0.839 (0.449–1.570) | 0.584 |
Grade |  |  < 0.001 |  |  |
 I | Reference |  | Reference |  |
 II | 1.668 (0.975–2.856) | 0.062 | 1.346 (0.773–2.343) | 0.294 |
 III | 6.837 (3.981–11.741) |  < 0.001 | 2.324 (1.235–4.375) | 0.009 |
 IV | 9.505 (5.654–15.978) |  < 0.001 | 3.148 (1.710–5.795) |  < 0.001 |
Stage |  |  < 0.001 |  |  |
 I | Reference |  | Reference |  |
 II | 1.668 (1.029–2.706) | 0.038 | 0.481 (0.145–1.596) | 0.232 |
 III | 3.353 (2.173–5.175) |  < 0.001 | 0.480 (0.149–1.544) | 0.218 |
 IVA | 5.950 (3.970–8.917) |  < 0.001 | 0.462 (0.130–1.638) | 0.232 |
Tumor (T) stage |  |  < 0.001 |  |  |
 T1 | Reference |  | Reference |  |
 T2 | 2.199 (1.454–3.325) |  < 0.001 | 3.162 (1.059–9.440) | 0.039 |
 T3 | 4.210 (2.773–6.390) |  < 0.001 | 4.300 (1.501–12.316) | 0.007 |
 T4 | 5.440 (3.534–8.376) |  < 0.001 | 4.414 (1.439- 13.535) | 0.009 |
Node (N) stage |  |  < 0.001 |  |  |
 N0 | Reference |  | Reference |  |
 N1 | 2.972 (2.067–4.274) |  < 0.001 | 1.807 (0.226–14.438) | 0.577 |
 N2 | 4.849 (3.400–6.916) |  < 0.001 | 2.517 (0.300–21.156) | 0.395 |
Radiation |  |  < 0.001 |  |  |
 No | Reference |  | Reference |  |
 Yes | 2.074 (1.531–2.810) |  < 0.001 | 0.750 (0.525–1.072) | 0.114 |
Chemotherapy |  |  < 0.001 |  |  |
 No/unknown | Reference |  | Reference |  |
 Yes | 3.871 (2.569–5.832) |  < 0.001 | 1.721 (1.096–2.703) | 0.018 |
Laterality | Â | 0.648 | Â | Â |
 Left | Reference |  |  |  |
 Right | 0.935 (0.702–1.246) | 0.648 |  |  |
Marriage | Â | 0.327 | Â | Â |
 No | Reference |  |  |  |
 Yes | 0.866 (0.649–1.154) | 0.326 |  |  |
Lymph node ratio 9%) |  |  < 0.001 |  |  |
 LNR0 | Reference |  | Reference |  |
 LNR1 | 3.647 (2.731–4.869) |  < 0.001 | 0.868 (0.114–6.602) | 0.891 |