Figure 1

Overall profile of DSRG expressions in cell components of osteosarcoma tumor microenvironment. (A) The hierarchical heatmap illustrating CNVs in lesions from the osteosarcoma sample. (B) The t-SNE plot showing the seven cell clusters including one malignant cluster from the osteosarcoma sample. (C) Scatter plot showing the overall expression feature of DSRGs in each cell cluster. (D) Dotplots showing the 24 DSRGs expression across the seven cellular clusters, where the size of dots represents the proportion of cells expressing the genes and the color spectrum indicates the mean expression levels of the genes. (E) Scatter plot showing the recognized cell cycle of each cell. (F) The ridge plot illustrating the correlation between DSRGs expression and the cell cycle, the red one represent the cell amount in G1 phase, the green one represent the cell amount in S phase, the blue one represent the cell amount in G2M phase.