Figure 2

Identification of disulfidptosis-related molecular clusters in OS. (A) Representative cumulative distribution function (CDF) curves for sample clustering. (B) CDF delta area curves. (C) Consensus clustering matrix when k = 4. (D) PCA showing the distribution of four subtypes. (E) The intersection of differentially expressed genes among three main disulfidptosis-related molecular clusters. (F) Circle plot of GO pathway activities of the intersections genes, the shade of the color shows the increasing of the z-score, the blue dot illustrate the downregulated ones and the red dot illustrate the downregulated ones. (G) Circle plot of KEGG pathway activities of the intersections genes, the shade of the color shows the increasing of the z-score, the blue dot illustrate the downregulated ones and the red dot illustrate the downregulated ones. (H) Heatmap of GO pathway activities of the intersections genes, the shade of the color shows the increasing of the logFC. (I) Heatmap of KEGG pathway activities of the intersections genes, the shade of the color shows the increasing of the logFC. (J) Identification of molecular and immune characteristics among the three disulfidptosis-related molecular clusters. (K) Boxplots showing the infiltration scores of immune cells among the disulfidptosis-related molecular clusters.