Figure 6

DSRGs-related intercellular communication analysis between OS cells and the niche cells in OS TME. (A) Heatmap of ligand–target DSRGs interaction in the niche cells-OS cells communication, the darker of the color indicate the higher regulation potential of the ligand to the gene. (B) Top ligand–receptor interaction pairs in the niche cells-OS cells communication, the darker of the color indicate the higher interaction potential of the ligand to the gene. (C) Predicted signaling pathways of HMGB1-ACTB axis.