Table 5 Gender differences in MCI sensitivity and specificity with different blood and cognitive measures.

From: Serum neurofilament light chain and inflammatory cytokines as biomarkers for early detection of mild cognitive impairment

 

Men (n = 68)

Women (n = 73)

AUC

Cut off

Sensitivity

Specificity

P

AUC

Cut off

Sensitivity

Specificity

P

IL-1β

0.525

2.12

0.132

0.682

0.747

0.661

0.92

0.750

0.644

0.026

IL-6

0.719

1.33

0.800

0.667

0.005

0.596

0.58

0.957

0.875

0.185

TNF-α

0.564

1.50

0.912

0.86

0.408

0.677

3.26

0.792

0.592

0.023

NfL

0.663

2016.7

0.450

0.875

0.035

0.625

2156.7

0.458

0.826

0.085

BNT

0.692

27.5

0.900

0.417

0.013

0.700

23.5

0.667

0.653

0.006

NfL + IL-6

0.719

0.51

0.800

0.667

0.005

0.500

0.24

0.875

0.407

0.040

NfL + BNT

0.777

0.47

0.800

0.708

P < 0.001

0.700

0.31

0.667

0.653

0.006

  1. IL-1β: Interleukin 1β; IL-6: Interleukin 6; TNFα: Tumor necrosis factor α; NfL: Neuroflament light chain; BNT: Boston naming test.
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