Figure 2 | Scientific Reports

Figure 2

From: In-vitro and in-vivo assessment of nirmatrelvir penetration into CSF, central nervous system cells, tissues, and peripheral blood mononuclear cells

Figure 2

Plasma ((a) black) and CSF ((b) red) observed versus Bayesian predicted plots for all animals compared to EC90Un_adjusted values (dotted black line). The black and red lines represent the predictions where the filled circles represent the observed collected concentrations. A median of 16% of all the predicted CSF concentrations in rats were > 3xEC90Un_adjusted. *Units on plot converted to ng/mL for consistency. NMR nirmatrelvir, CSF cerebrospinal fluid, EC90 90% maximal effective concentration (unadjusted for protein binding given CSF, 90.5 ng/mL 0.0905 mg/L and 271.5 ng/mL = 0.2715 mg/L).

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