Figure 3 | Scientific Reports

Figure 3

From: In-vitro and in-vivo assessment of nirmatrelvir penetration into CSF, central nervous system cells, tissues, and peripheral blood mononuclear cells

Figure 3

Violin plots of tissue and PBMC AR for NMR. The highest median NMR tissue AR was observed in the liver and kidney, while the lowest median NMR tissue AR was observed in brain tissue. *Rat 7 only completed 1 day of treatment, no PMBC levels available. Rats 1 and 2 do not have lung or heart NMR concentrations due to tissue processing complications. #Calculated as a ratio of observed plasma NMR levels vs. tissue/PBMC levels at equivalent time of sampling. ^Calculated using plasma level predictions vs. observed concentrations due to plasma NMR levels being BLOQ. AR accumulation ratio, BLOQ below level of quantification, IQR interquartile range.

Back to article page