Figure 2
From: Detection of clonal plasma cells in POEMS syndrome using multiparameter flow cytometry
The immunophenotype of the monoclonal plasma cells in POEMS syndrome. The immunophenotype of CD19 and CD56 in the identified clonal PCs using (A) MM-flow (n = 9) and (B) POEMS-flow (n = 18) are shown. The size of the circle in the figure indicates the number of cases with different immunophenotypes of CD19 and CD56 (CD19−/CD56+ or CD19−/CD56− or CD19+/CD56−). (A) Five (55.6%) were CD19−/CD56+ and three (33.3%) were CD19−/CD56− in MM-flow. (B) Five (27.8%) were CD19−/CD56+ and 12 (66.7%) were CD19−/CD56− in POEMS-flow. (C) A comparison of CD38 mean fluorescence intensity (MFI) between monoclonal and normal plasma cells (PCs) analyzed using POEMS-flow is shown. The CD38 MFI of monoclonal PCs was significantly lower than that of normal PCs (P = 0.005), with median MFI values of 13,074.5 (range 2355–31,472) for monoclonal PCs and 20,778 (range 3674–34,672) for normal PCs.
