Table 1 Systems where we can expect vulnerability near the edge. Specific questions for follow-up research.

From: Transformation starts at the periphery of networks where pushback is less

System

background

question

Psychiatric disorders

Many psychiatric disorders correspond to networks of symptoms such as insomnia, rumination, and depressed mood that are mutually reinforcing11,12

Are central symptoms in such networks more resistant to treatment?

Meta-populations

Meta-populations or ecosystems such as coral reefs or remains of forests often occur in a spatial network of patches where migration between the patches enhances resilience and creates a ‘rescue effect’9,10,35,39,40

Should protective measures, but also restoration efforts, focus on the peripheral rather than the core patches?

Science

It may be more difficult to get an entirely different idea if you build on the same information41

Is there an optimal level of disconnect between research groups?

Art

Artists are influenced by their peers and surroundings27,41

Is art from isolated artists more original?

Power grids

From a single element, failure may cascade through power grids as loads are shifted to nearby elements which are then pushed beyond capacity42,43

Is failure due to overload more likely to start from a peripheral element?

Financial networks

Banks and other financial institutions depend on each other through a partly invisible network of loans and other agreements8,44

Is systemic failure most likely to start from peripheral banks?