Figure 5 | Scientific Reports

Figure 5

From: Exercise ameliorates muscular excessive mitochondrial fission, insulin resistance and inflammation in diabetic rats via irisin/AMPK activation

Figure 5

Exercise and cycloRGDyk treatment affect the Irisin/AMPK pathway in the skeletal muscle of diabetic rats. (A) RT-qPCR analysis of soleus muscle FNDC5 expressions. (B–D) Western blot analysis of FNDC5/irisin and p-AMPK expression in soleus muscle of rats between groups. Con control, DM Type 2 diabetes, Ex Type 2 diabetes combined with exercise, ExRg Type 2 diabetes combined with exercise plus cycloRGDyk, FNDC5 Fibronectin type III ___domain-containing protein 5, AMPK AMP-activated protein kinase. *Denotes the significant difference compared with Con group (p < 0.05); #indicates the significant difference compared with DM group (p < 0.05); §presents the significant difference compared with Ex group (p < 0.05).

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