Figure 6

Exercise-related beneficial effects could be partially blocked by cycloRGDyk treatment in diabetic rats. (A) H&E staining of representative Skeletal muscle sections. (B) Experimental schedules. (C,D) Levels of FBG and FIN. (E) Insulin resistance index. (F) Levels of HbA1c. (G) Fasting blood glucose level was determined after insulin injection for 30, 60, 90 and 120 min. (H) Area under the insulin tolerance curve in different groups. (I–L) Levels of lipid parameters. (M–O) Immunofluorescence and its semiquantitative analysis for evaluating IL-1β and TNF-α expression in soleus muscle of rats between groups. (P–Q) Western blot analysis of IL-1β and TNF-α expression in soleus muscle of rats between groups. Ex Type 2 diabetes combined with exercise, ExRg Type 2 diabetes combined with exercise plus cycloRGDyk, FBG Fasting blood glucose, FIN Fasting insulin, TC Total cholesterol, TG Triglyceride, HDL-C High-density lipoprotein cholesterol, LDL-C Low-Density Lipoprotein Cholesterol, IL-1β interleukin-1β, TNF-α tumor necrosis factor-α, HbA1c Glycated haemoglobin, ITT Insulin tolerance test. ^§Presents the significant difference compared with the Ex group (p < 0.05).