Figure 7 | Scientific Reports

Figure 7

From: Exercise ameliorates muscular excessive mitochondrial fission, insulin resistance and inflammation in diabetic rats via irisin/AMPK activation

Figure 7

The effect of exercise in regulating muscular excessive mitochondrial fission was blocked by cycloRGDyk injection. (A–C) Immunofluorescence and its semiquantitative analysis for evaluating Drp1 and Fis1 expression in soleus muscle of rats between groups. (D) RT-qPCR analysis of the mRNA expression of Drp1, Fis1, MFF and MFN2 in soleus muscle of rats between groups. (E,F) Western blot analysis of Drp1, Fis1, MFF and MFN2 expression in soleus muscle of rats in Ex and ExRg group. Ex Type 2 diabetes combined with exercise, ExRg Type 2 diabetes combined with exercise plus cycloRGDyk, Drp1 Dynamin-related protein 1, Fis1 Fission protein 1, MFF Mitochondrial fission factor, MFN2 Mitofusin 2. §Presents the significant difference compared with the Ex group (p < 0.05).

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