Table 4 Comparison of key exercise parameters of patients depending on their oxygen uptake at BL4—univariate analysis.

From: Cardiac diastolic maladaptation is associated with the severity of exercise intolerance in sickle cell anemia patients

Exercise characteristics

BL4% \({\dot{{\text{V}}}{\text{O}}}_{2{\text{peakth}}}\) < 39 (n = 14)

BL4% \({\dot{{\text{V}}}{\text{O}}}_{2{\text{peakth}}}\) ≥ 39 (n = 15)

p

Values at BL4

 \({\dot{{\text{V}}}{\text{O}}}_{2{\text{peakth}}}\)(%)

34.4 ± 5.4

46.2 ± 6.8

 < 0.001

\({ \dot{{\text{W}}}}_{{\text{maxth}}}\)(%)

33.0 ± 4.7

42.8 ± 9.6

0.002

 AV-O2Δ (mL L−1 m−2)

112 ± 33

147 ± 59

0.07

\({\mathrm{ HR}}_{{\text{maxth}}}\)(%)

80.7 ± 11.9

82.5 ± 16.1

0.73

\(\dot{\mathrm{ V}}{\text{E}}\)/ \({\dot{{\text{V}}}{\text{CO}}}_{2}\) slope

36.7 ± 8.3

34.4 ± 6.5

0.42

 Oxygen saturation (%)

94.5 ± 5.2

95.5 ± 5.4

0.62

 MET

3.6 ± 0.6

4.7 ± 1.0

0.003

BL4/resting value ratio

 AV-O2Δ ratio

1.6 ± 0.2

1.7 ± 0.6

0.44

 Cardiac index ratio

2.1 ± 0.3

2.1 ± 0.5

0.59

 e′ ratio

1.4 ± 0.2

1.6 ± 0.3

0.04

 E/e′ ratio

1.2 ± 0.2

1.0 ± 0.2

0.003

 MAP ratio

1.2 ± 0.2

1.2 ± 0.1

0.70

  1. Significant values are in bold.
  2. Continuous data are presented mean ± SD. BL4 blood lactate concentration of 4 mmol/l, \({\dot{V}O}_{2peakth}\) VO2 expressed as % of the maximum predicted, \({\dot{W}}_{maxth}\) power output expressed as % of the maximum predicted, MET metabolic equivalent of task, AV-O2Δ arteriovenous oxygen difference, %HRmaxth heart rate expressed as % of the maximum predicted, e′ lateral early diastolic myocardial velocity, E mitral inflow early filling velocity, MAP mean arterial pressure.