Table 2 Genome-wide significant loci associated with sRAGE levels in plasma.

From: The Gly82Ser polymorphism in the receptor for advanced glycation endproducts increases the risk for coronary events in the general population

Genomic locus

Chr

BP

rsID

A1

A2

EAF

Beta*

SE

P

R2†

Nearest gene

1

6

31109567

rs116653040

G

C

0.075

− 0.244

0.041

2.4E − 09

0.008

CCHCR1

 

6

32151443

rs2070600

T

C

0.051

− 0.392

0.049

9.4E − 16

0.015

AGER

 

6

32155581

rs204993

G

A

0.257

− 0.176

0.025

1.1E − 12

0.012

PBX2

2

12

617308

rs7306778

T

C

0.169

− 0.187

0.029

9.0E − 11

0.010

B4GALNT3

  1. *Beta coefficient given as normalized protein expression per allele increment, adjusted for age, age2, sex and the first to third principal components of population structure.
  2. †R2, proportion of variance explained.
  3. Chr, chromosome; BP, base pair; A1, effect allele; A2, other allele; EAF, effect allele frequency; SE, standard error.
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