Figure 5

Multivariable Mendelian randomization to assess the direct effects on CHD. Multivariable Mendelian randomization involves mutual adjustment for serum SHBG levels and blood lipid levels. SHBG sex hormone-binding globulin, CHD coronary heart disease, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, VLDL-C very low-density lipoprotein cholesterol, TG triglycerides, HCL hypercholesterolemia, OR odds ratio, CI confidence interval.