Figure 5
From: Expression and potential molecular mechanism of TOP2A in metastasis of non-small cell lung cancer
TOP2A promotes non-small cell lung cancer progression via Wnt/β-catenin signaling pathway. (A) After Wnt3a gene knockdown, the mobility and invading capabilities of TOP2A-overexpressing cells were evaluated using the transwell assay. (B,C) Expression of components of Wnt/β-catenin signaling pathway and EMT-related proteins was examined using western blotting. (D) Flow cytometry was utilized to examine the cell cycle. (E) Analysis of apoptosis via flow cytometry. *P < 0.05, **P < 0.01, ***P < 0.001 or ****P < 0.0001; ns: not signiffcant.
