Figure 1
From: ACLS4 could be a potential therapeutic target for severe acute pancreatitis
Transcriptome analysis of acute pancreatitis mouse model. (A) Volcano plot comparing global gene expression patterns between CIP and Sal treatment mice. The red dots (n = 2424) and blue dots (n = 1371) represent upregulated (FC > 1.5) and downregulated (FC < 0.67) differentially expressed genes with statistical significance (adjusted P value < 0.05), respectively. (B) Gene Ontology (GO) enrichment circle plot of differentially expressed genes in CIP versus Sal treatment mice. (C,D) Bubble plots of KEGG pathways32 enriched in upregulated (C) and downregulated (D) genes in CIP versus Sal treatment mice. Cycle size represents the gene numbers in each pathway, color gradients represent the adjusted P value of each pathway.
