Table 4 Subgroups analyses of the effect of SII on serum anti-aging protein klotho.

From: L-shaped association of systemic immune-inflammation index (SII) with serum soluble α-Klotho in the prospective cohort study from the NHANES database

Subgroups

N

β (95% CI), p value

p for interaction

Age

0.5669

 40–59

7442

 − 0.06 (− 0.08, − 0.04), < 0.001

 

 60–69

3833

 − 0.07 (− 0.10, − 0.04), < 0.001

 

 70–79

2426

 − 0.08 (− 0.11, − 0.05), < 0.001

 

Gender

0.4890

 Men

6641

 − 0.06 (− 0.08, − 0.04), < 0.001

 

 Women

7060

 − 0.07 (− 0.10, − 0.05), < 0.001

 

Race

0.4282

 Mexican American

2180

 − 0.08 (− 0.12, − 0.04), < 0.001

 

 Other Hispanic

1571

 − 0.11 (− 0.16, − 0.05), < 0.001

 

 Non-Hispanic White

5901

 − 0.06 (− 0.09, − 0.04), < 0.001

 

 Non-Hispanic Black

2702

 − 0.06 (− 0.10, − 0.02), 0.0029

 

 Other Race—Including Multi-Racial

1347

 − 0.06 (− 0.10, − 0.02), 0.1041

 

Smoking

0.1978

 ≥ 100 cigarettes in life

6648

 − 0.06 (− 0.08, − 0.04), < 0.001

 

 < 100 cigarettes in life

7053

 − 0.08 (− 0.10, − 0.06), < 0.001

 

Alcohol

0.5776

 ≥ 12 drinks/year

8976

 − 0.06 (− 0.08, − 0.04), < 0.001

 

 < 12 drinks/year

4725

 − 0.07 (− 0.10, − 0.05), < 0.001

 

Diabetes

0.2736

 Yes

2462

 − 0.09 (− 0.12, − 0.05), < 0.001

 

 No

11,239

 − 0.06 (− 0.08, − 0.05), < 0.001

 

Hypertension

0.4170

 Yes

6365

 − 0.07 (− 0.10, − 0.05) < 0.001

 

 No

7336

 − 0.06 (− 0.08, − 0.04) < 0.001

 
  1. Subgroup analysis for the association between SII and serum anti-aging protein klotho. None of the stratifications including gender, age, race, marital status, education level, smoking status, alcohol, diabetes and hypertension affected the association of SII and klotho.
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