Figure 4 | Scientific Reports

Figure 4

From: P4HA2 promotes proliferation, invasion, and metastasis through regulation of the PI3K/AKT signaling pathway in oral squamous cell carcinoma

Figure 4

Influence of P4HA2 expression on OSCC cells’ metastasis and invasion. (A, B) Migration and invasion tests examined the cell migration ability in the sh-P4HA2, sh-GFP, pcDNA3.1-p4HA2, and pcDNA3.1 groups of SCC-25 and SCC-9, analyzed separately. The data indicated that P4HA2 could positively regulate the OSCC cells' ability to migrate and invade. (C) A WB test was used to measure MMP-9 and MMP-2 expression in the sh-P4HA2, sh-GFP, pcDNA3.1-p4HA2, and pcDNA3.1 groups of SCC-25 and SCC-9. The data indicated that P4HA2 knockdown suppressed MMP-9 and MMP-2 expression. Furthermore, we found opposite results when P4HA2 was overexpressed. N = 3. *:p less than 0.05, **:p less than 0.01, ***:p less than 0.001, ****:p less than 0.0001.

Back to article page