Figure 6 | Scientific Reports

Figure 6

From: P4HA2 promotes proliferation, invasion, and metastasis through regulation of the PI3K/AKT signaling pathway in oral squamous cell carcinoma

Figure 6

Down-regulated P4HA2 expression reduced OSCC cell proliferation and migration in vivo. (A) Based on the in vivo fluorescence imaging system, the Pulmonary metastasis model was identified for the evaluation of the migration capacity; the fluorescence intensity was analyzed. Next, the lungs of mice were isolated. (B) H&E staining was applied for the analysis of mice lungs' pulmonary metastasis cells (×100). (C) Effects of lentivirus infection on tumorigenicity of cells in the respective group. (D) The respective group material of body weight and tumor volume of mice. (E) H&E staining was used to indicate the pulmonary metastasis cells of mice lungs and the nucleus atypia of tumors. N = 6. *:p less than 0.05, **:p less than 0.01, ***:p less than 0.001, ****:p less than 0.0001.

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