Table 5 Odds ratios for the presence of left ventricular diastolic dysfunction according to thyroid hormone levels and function.

From: The association between TSH and thyroid hormones in the normal or subclinical dysfunction range with left ventricular diastolic dysfunction

 

Unadjusted

Model 1

Model 2

OR (95% CI)

P value

OR (95% CI)

P value

OR (95% CI)

P value

Total subjects (N = 26,289)

TSH (per 1 µIU/ml increase)

1.05 (1.02–1.09)

0.001

1.05 (1.01–1.09)

0.025

1.05 (1.01–1.09)

0.022

FT4 (per 1 ng/dL decrease)

2.11 (1.01–4.44)

0.048

1.62 (0.77–3.38)

0.202

1.56 (0.74–3.29)

0.242

T3 (per 10 ng/dL decrease)

1.16 (1.07–1.25)

 < 0.001

1.11 (1.03–1.20)

0.005

1.14 (1.05–1.23)

0.001

SC-hypothyroid (ref. euthyroid)

TSH > 4.2 µIU/ml

1.81 (1.31–2.51)

 < 0.001

1.36 (1.01–1.89)

0.049

1.36 (1.01–1.89)

0.049

TSH ≥ 10.0 µIU/ml

2.48 (1.01–6.08)

0.048

1.90 (1.07–4.74)

0.049

1.99 (1.07–5.00)

0.047

SC-thyrotoxicosis (ref. euthyroid)

TSH < 0.4 µIU/ml

1.31 (0.48–3.55)

0.594

0.91 (0.33–2.51)

0.861

0.93 (0.34–2.56)

0.884

TSH ≤ 0.1 µIU/ml

2.77 (0.87–8.78)

0.083

2.32 (0.71–7.55)

0.164

2.49 (0.76–8.19)

0.134

Euthyroid subjects (N = 22,197)

TSH (per 1 µIU/ml increase)

1.02 (0.86–1.21)

0.809

0.97 (0.82–1.15)

0.726

0.99 (0.83–1.17)

0.865

FT4 (per 1 ng/dL decrease)

1.77 (0.74–4.22)

0.199

0.52 (0.22–1.25)

0.143

0.56 (0.23–1.36)

0.201

T3 (per 10 ng/dL decrease)

1.16 (1.06–1.26)

0.001

1.11 (1.02–1.21)

0.019

1.14 (1.04–1.24)

0.006

  1. Model 1 was adjusted for age and sex. Model 2 was adjusted for age, sex, body mass index,  hypertension, diabetes, dyslipidemia, and current smoking status.
  2. TSH thyroid-stimulating hormone, FT4 free thyroxine, T3 triiodothyronine, DT deceleration time, OR odds ratio, CI confidence interval, SC subclinical.
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