Figure 3

Functional analysis of genes promoting or inhibiting HBD2 expression. (a) Occurrence of HBD2 with promoting or inhibiting genes in the literature. The association queries between “HBD2” and the “hit gene” were submitted to PubMed (NCBI). Results are presented as the percentage of matches linking “HBD2” with the “hit gene” (black dots), compared to no matches (white dots), for promoting and inhibiting genes. (b) Genomic distribution of genes promoting or inhibiting HBD2 expression. Promoting (white bars) and inhibiting (black bars) genes were mapped in the human genome using GenBank (NCBI). Results are presented as the percentage of promoting or inhibiting genes located on each of the 23 chromosome pairs. (c) Subcellular locations of proteins encoded by genes promoting or inhibiting HBD2 expression. Promoting (white bars) and inhibiting (black bars) proteins encoded by the identified genes were classified using UniProtKB (UniProt). Results are presented as the percentage of promoting or inhibiting genes distributed according to their cellular ___location among nucleus, cytoplasm, membrane, cytoskeleton, endoplasmic reticulum, Golgi apparatus, mitochondrion, secreted, or unknown. (d) Biological processes involving proteins encoded by genes promoting or inhibiting HBD2 expression. Promoting (white bars) and inhibiting (black bars) proteins encoded by the identified genes were categorized using UniProtKD (UniProt). Results are presented as the percentage of promoting or inhibiting genes distributed according to their involvement in biological processes among gene regulation, signal transduction, metabolism, transport, cell cycle, or other.