Figure 3 | Scientific Reports

Figure 3

From: JNJ-77242113, a highly potent, selective peptide targeting the IL-23 receptor, provides robust IL-23 pathway inhibition upon oral dosing in rats and humans

Figure 3

Treatment with JNJ-77242113 protected against body weight loss and signs of inflammation in a TNBS-induced colitis rat model. (A) Mean percent change in body weight from baseline over time (error bars represent SEM; **P < 0.001, ****P < 0.0001), (B) colon weight/length ratio at Day 7 (**P < 0.01, ****P < 0.0001). Bars represent medians and error bars denote interquartile ranges. n = 10 per dose group per experiment; data from up to 3 experiments were combined. ns not significant, SEM standard error of the mean, TNBS trinitrobenzene sulfonic acid.

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