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Figure 1

From: Icariin alleviates cisplatin-induced premature ovarian failure by inhibiting ferroptosis through activation of the Nrf2/ARE pathway

Figure 1

ICA improves ovarian function in cisplatin-induced POF. (A) Gross appearance of ovaries between indicated groups. (B-D), Comparison of body weight (B), ovarian weight (C) and ovarian index (D) of mice after treatment in each group (n = 5). (E), Representative images of HE staining of mice at various stages of the estrous cycle (n = 5). Scale bars, 50 µm. (F), Percentage of estrous cycle in each stage. P, proestrus; E, estrus; M, metestrus; D, diestrus. (G), Representative graphs for monitoring the estrous cycle of each group of mice for 21 consecutive days. (H), HE staining of the ovaries in each group. Black arrows indicate primordial follicles; red arrows indicate primary follicles; green arrows indicate secondary follicle; blue arrows indicate antral follicles. Scale bars, 100 µm. (I), Ratio of number of growing follicles (primary follicle, secondary follicle and antral follicle) to primordial follicles in mice (n = 6). (J), Following therapy, the quantity of follicles at each stage in every mouse group (n = 6). PMF, primordial follicle; PF, primary follicle; SF, secondary follicle; AF, antral follicle. Data are presented as mean ± SEM, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, ns, non-statistically significant.

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