Figure 9 | Scientific Reports

Figure 9

From: Icariin alleviates cisplatin-induced premature ovarian failure by inhibiting ferroptosis through activation of the Nrf2/ARE pathway

Figure 9

ICA promotes Nrf2 release by competing with Nrf2 to bind Keap1. (A) Molecular docking of ICA to the key target KEAP1. (B), The KEAP1 protein is represented as a slate cartoon model, ICA is shown as a cyan stick, and their binding sites are shown as magentas stick structures. The hydrogen bond, ionic interactions, and hydrophobic interactions are depicted as yellow, magentas and green dashed lines, respectively.

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