Figure 1
From: The metabolic role of vitamin D in children’s neurodevelopment: a network study
Overall scheme of the analysis. (a) The metabolomics matrix containing the metabolite levels of 381 VDAART children was used as the input to the LIONESS algorithm. (b) Pearson correlation coefficients between each pair of metabolites were calculated to build the aggregate correlation network associated with the metabolomics matrix. Only edges with high correlation coefficients are shown for visualization purposes. (c) LIONESS reconstructed the sample-specific metabolic networks based on Eq. (1). (d) The LIONESS edge weights for each pair of metabolites were regressed against the children’s phenotypic traits. (e) We selected edges that are statistically associated with the interaction term between children’s ASQ-comm scores and either maternal or offspring vitamin D levels. These edges constitute the VDI network.
