Figure 1 | Scientific Reports

Figure 1

From: Identifying an immunosenescence-associated gene signature in gastric cancer by integrating bulk and single-cell sequencing data

Figure 1

Confirmation of senescence as a hallmark of GC at transcriptomic and genomic level. (A) Heatmap of the expression levels of the ISGs in TCGA-STAD. (B) Survival analysis of different immunosenescence ssGSEA scores. (C) T cell dysfunction and exclusion status of different ssGSEA classes. (D) cytotoxicity scores comparison. (E) SNV and (F) SCNA G-score analyses. PPI, Protein–protein interaction; ISGs, immunosenescence-related genes; TCGA-STAD, The Cancer Genome Atlas stomach adenocarcinoma; ssGSEA, single-sample gene set enrichment analysis; SNV, single nucleotide variant; SCNA, somatic copy number alteration. ns p ≥ 0.05, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.

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