Figure 3

Manhattan of genome-scale p-values for testing of regression coefficients in DNA methylation between F2 cord blood and F1 parents at different ages of the mothers (at birth, 18 years, early pregnancy, and late pregnancy) and during pregnancy for fathers. CpGs that reached statistical significance are highlighted in green, while the remaining CpGs have alternating colors of blue and orange for different genes. Two horizontal lines indicate cutoff p-values: the blue line represents \({10}^{-5}\) and red line represents the Bonferroni adjusted alpha \({1.47\times 10}^{-7}\).