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Figure 1

From: Chemotherapy increases CDA expression and sensitizes malignant pleural mesothelioma cells to capecitabine treatment

Figure 1

CDA expression in MPM cell lines and patient samples. (A) Schematic representation of the role of CDA in capecitabine metabolism and its role in the pyrimidine de novo and salvage pathways. (B) Western blot analysis of basal CDA protein expression in the indicated MPM cell lines. The epithelial NSCLC cell line H358 was included as a positive control for CDA expression. (C) Graphical representation of CDA mRNA expression data from selected cell lines from the RNAseq Gene Expression Atlas. (D) In silico analysis of gene expression data from MPM tumor samples from patients in the TCGA database. (E) Correlation analysis of gene expression data from tumors of mesothelioma patients derived from the cBioPortal. (F) Analysis of MESO-1 cell viability normalized to that of the solvent-treated control; n = 3 independent experiments. (G) Analysis of the viability of JL-1 cells normalized to that of solvent-treated controls. The experiments were performed in triplicate and were replicated at least twice.

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