Figure 3
From: Adipsin-dependent adipocyte maturation induces cancer cell invasion in breast cancer
Suppression of tumor growth in Cfd KO mice. (A) Relative expression level of Cfd mRNA in murine mature adipocytes and EO771cells. Expression levels were normalized to Actb mRNA expression levels. Data are presented as mean ± SD. n = 4, **p < 0.01. (B) Concentration of adipsin (CFD) in the serum of WT or Cfd KO mouse bearing EO771 tumor. Data are presented as mean ± SD. n = 7 (WT) and 6 (KO), **p < 0.01. (C) The capacity of breast cancer EO771 cells (1 × 105 cells/site) to form tumors upon in vivo transplantation into the mammary fat pad region of C57BL/6 mice was suppressed by Cfd KO in the mouse. Tumor growth was monitored by caliper measurements twice a week. Data are presented as mean ± SD. n ≥ 3, *p < 0.05.
