Figure 4
From: Adipsin-dependent adipocyte maturation induces cancer cell invasion in breast cancer
Suppression of tumor progression in Cfd KO mice. (A) Histological analysis of the tumor invasion fronts. At the tumor-mammary adipose tissue interfaces, much thicker fibrotic capsules with inflammatory cells and tumor cell invasion were formed for the tumors grown in WT mice compared to those grown in Cfd KO mice. Upper panels, H&E (hematoxylin and eosin), silver and Masson’s trichrome staining images are presented. Dotted lines: border between tumor and mammary adipose tissue, white arrows: thick fibrotic capsules. Lower panels, thickness of the fibrotic capsule at the tumor invasion front facing the mammary adipose tissue (tumor-adipose tissue interface). n of the analyzed mice ≥ 3, **p < 0.01. (B) Number of mice bearing lung metastases. The presence of lung metastasis was histologically evaluated. White arrows: tumor metastases. n = 11 (WT) and 10 (KO), *p < 0.05.
