Table 1 The MR analysis results for the causal effect of microbiota on IC/BPS (p-value < 1 × 10−5).
Exposure | SNPs | F-statistic | Method | OR (95% CI) | p-value | Heterogeneity Cochran’s Q (p-value) | MR Egger Intercept (p-value) |
|---|---|---|---|---|---|---|---|
G_Bacteroides | 12 | 22.620 | IVW | 4.273 (1.361, 13.413) | 0.013 | 1.309 (0.998) | 0.031 (0.879) |
WM | 3.959 (0.943, 16.611) | 0.060 | – | ||||
MR Egger | 2.648 (0.006, 1143.080) | 0.761 | 1.285 (0.996) | ||||
G_Haemophilus | 14 | 23.285 | IVW | 2.175 (1.172, 4.036) | 0.014 | 10.262 (0.672) | − 0.015 (0.858) |
WM | 1.580 (0.642, 3.886) | 0.319 | – | ||||
MR Egger | 2.483 (0.527, 11.713) | 0.273 | 10.229 (0.596) | ||||
G_Veillonella | 11 | 21.394 | IVW | 2.379 (1.037, 5.458) | 0.041 | 4.854 (0.847) | − 0.183 (0.563) |
WM | 2.743 (0.920, 8.180) | 0.070 | – | ||||
MR Egger | 25.627(0.011, 60,440.870) | 0.437 | 4.490 (0.810) | ||||
G_Coprococcus1 | 14 | 21.985 | IVW | 2.704 (1.118, 6.542) | 0.027 | 13.698 (0.395) | − 0.028 (0.735) |
WM | 1.335 (0.402, 4.427) | 0.637 | - | ||||
MR Egger | 3.922 (0.395, 38.987) | 0.266 | 13.563 (0.329) | ||||
G_Butyricimonas | 17 | 22.181 | IVW | 2.265 (1.151, 4.455) | 0.018 | 11.659 (0.767) | 0.159 (0.147) |
WM | 1.925 (0.761, 4.869) | 0.167 | – | ||||
MR Egger | 0.362 (0.031, 4.184) | 0.428 | 9.324 (0.860) | ||||
F_Bacteroidaceae | 12 | 22.620 | IVW | 4.273 (1.361, 13.413) | 0.013 | 1.309 (0.998) | 0.031 (0.879) |
WM | 3.959 (0.936, 16.737) | 0.061 | – | ||||
MR Egger | 2.648 (0.006, 1143.080) | 0.761 | 1.285 (0.996) | ||||
F_Christensenellaceae | 12 | 19.336 | IVW | 2.627 (1.045, 6.605) | 0.040 | 8.999 (0.622) | 0.012 (0.871) |
WM | 2.373 (0.650, 8.667) | 0.191 | – | ||||
MR Egger | 2.258 (0.305, 16.698) | 0.444 | 8.971 (0.535) | ||||
O_Lactobacillales | 19 | 22.397 | IVW | 2.142 (1.024, 4.480) | 0.043 | 14.477 (0.697) | 0.054 (0.468) |
WM | 2.128 (0.733, 6.182) | 0.165 | – | ||||
MR Egger | 1.135 (0.182, 7.081) | 0.894 | 13.926 (0.672) |
