Table 1 Structures and in vitro anti-α-glucosidase activities of bis-4-hydroxycoumarin-phenoxy-1,2,3-triazole-N-phenylacetamide derivatives 5a-m.

From: Design of new α-glucosidase inhibitors based on the bis-4-hydroxycoumarin skeleton: Synthesis, evaluation, and in silico studies

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Compound

R

IC50 (µM)

Compound

R

IC50 (µM)

5a

H

37.1 ± 0.7

5h

3-Cl

85.4 ± 2.3

5b

2-CH3

50.2 ± 1.7

5i

2,4-Dichloro

6.0 ± 0.2

5c

4-CH3

41.1 ± 1.1

5j

2-Br

28.8 ± 1.0

5d

2,4-Dimethyl

20.2 ± 0.8

5k

4-Br

81.7 ± 2.5

5e

2,4-Dimethoxy

52.0 ± 1.6

5l

3-NO2

16.3 ± 0.7

5f.

2-F

61.4 ± 2.2

5m

4-NO2

12.2 ± 0.4

5g

2-Cl

24.3 ± 0.7

Acarbose

750.0 ± 0.6