Figure 10 | Scientific Reports

Figure 10

From: Renogrit selectively protects against cisplatin-induced injury in human renal tubular cells and in Caenorhabditis elegans by harmonizing apoptosis and mitophagy

Figure 10

Renogrit decreased cisplatin-induced progeny decline, ROS generation and mitochondrial turnover in C. elegans. (a) Cisplatin (20–100 µg/ml) exposure decreased the progeny (brood size) of C. elegans (N2 strain). (b) Progeny analysis of Renogrit treated C. elegans (N2 strain). (c) Progeny analysis of C. elegans (N2 strain) induced with cisplatin (40 µg/ml) and treated with Renogrit (10–100 µg/ml) or NAC (4 mM). (d) Renogrit reduced the generation of ROS in cisplatin (40 µg/ml) exposed C. elegans (N2 strain). (e) Renogrit decreased nuclear localization (represented as green puncta) of SKN-1/NRF-2 in C. elegans (SYS81 strain) subjected to cisplatin (40 µg/ml). Magnification = 200 × . Data represented as mean ± S.E.M. ### and ***p < 0.001; # and *p < 0.05.

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