Figure 6 | Scientific Reports

Figure 6

From: Integrating network pharmacology with pharmacological research to elucidate the mechanism of modified Gegen Qinlian Decoction in treating porcine epidemic diarrhea

Figure 6

Determination of cytotoxicity and action concentrations of MGQD separately. (a) Cytotoxicity and TC50 curve of MGQD on IPEC-J2 cells. The cytotoxicity curve showed that within a certain concentration range, cytotoxicity increases with the increase of drug concentration. Morphology of IPEC-J2 cells (100X). The bar chart indicated that the activity of IPEC-J2 cells was significantly decreased when the concentration of MGQD was 10 mg/ml; whereas at a concentration of 2.5 mg/ml, there was no significant difference in cell activity compared to the normal cell group. (b) Determination and curve plot of suitable concentration of MGQD for IPEC-J2 cells infected with PEDV. The curve showed that the drug was only suitable for acting on IPEC-J2 cells infected with PEDV within a certain concentration range. Morphology of IPEC-J2 cells (40X). The bar chart demonstrated that the activity of PEDV-infected cells was significantly reduced, while 0.625 mg/ml MGQD significantly increased cells viability. *** P < 0.001.

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