Fig. 5 | Scientific Reports

Fig. 5

From: Metformin enhances the therapeutic effects of extracellular vesicles derived from human periodontal ligament stem cells on periodontitis

Fig. 5

Effects of Met on osteogenic differentiation of inflammatory PDLSCs induced by LPS. (A) The expression of inflammatory factors (IL-6 and IL-8) in PDLSCs were analyzed by qRT-PCR analysis (n = 3). (B) The osteogenic genes (ALP, Runx2 and OCN) in PDLSCs were analyzed by qRT-PCR analysis (n = 3). (CD) ALP staining and ALP activity (scale bar, 100 μm; n = 3). (EF) Photographs and quantitative analysis of alizarin red S staining (scale bar, 100 μm; n = 3). *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.

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