Fig. 8 | Scientific Reports

Fig. 8

From: In vivo and computational investigation of butin against alloxan-induced diabetes via biochemical, histopathological, and molecular interactions

Fig. 8

(A–E) In the photomicrographs, the pancreatic tissue sections are stained with H & E at a magnification of × 100 as compared to various experimental groups. (A) The appearance of normal islets of Langerhans (green arrow) and normal intralobular duct (yellow arrow) in normal control rats. (B) Abnormal structure of islet of Langerhans (orange arrow), and disorganized degenerative changes in the nuclei of the acini (black curved arrow) in alloxan control rats. (C) Mild hyperplasia of the islet cells (green arrow) and interlobular duct (black curved arrow) in alloxan + butin-25. (D) Histopathological architecture improved (green arrow) and reorganized interlobular duct (black curved arrow) in alloxan + butin-50. (E) Normal islets of Langerhans (green arrow) and exocrine acini (yellow arrow) exhibited in butin-50.

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