Fig. 5 | Scientific Reports

Fig. 5

From: Elastin-specific MR probe for visualization and evaluation of an interleukin-1β targeted therapy for atherosclerosis

Fig. 5

Laser-ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) for spatial localization of gadolinium in the atherosclerotic plaque area. (A) Unenhanced light microscopy image of an animal (n = 1) from the control group. (B) Corresponding image of the LA-ICP-MS visualizing the gadolinium-based elastin-specific probe within atherosclerotic plaque by the gadolinium signal. (C) Elastica van Gieson staining revealed a clear colocalization of gadolinium-accumulation with elastic fibers in the atherosclerotic plaque. *indicates the arterial lumen; #indicates the plaque area; Scale bars represent 100 µm.

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